La Compagnie is positioning the new route around a premium travel experience rather than high-capacity transatlantic transportation.
Passengers will have access to high-speed Wi-Fi, onboard entertainment and lounge facilities, while two checked bags will be included with the business-class service.
At Düsseldorf, passengers will have access to the DUS Sky Lounge, while La Compagnie provides lounge access for eligible passengers departing Newark.
The airline also plans to offer meals and beverages as part of its onboard service, including seasonal menus and French wines and Champagne.
With only 76 seats on the aircraft, the service will offer a considerably smaller cabin than the wide-body aircraft commonly used on major transatlantic routes.